ActiveXperts Knowledge Base Article 7500034
Yes, it is possible. Use smtp-legacy.office365.com on port 587 using STARTTLS.
Please note that the default security will not allow you to, and you'll end up with an error from the smtp-legacy.office365.com server saying:
535: 5.7.139 Authentication unsuccessful, user is locked by your organization's security defaults policy
For a solution, see: FAQ #7500036
Contact Support
If you cannot find an answer to your question(s) in our Knowledge Base, or if you need additional information or assistance, please contact our Customer Support using the Contact Support form:
Contact Support »